CD28, Costimulator or Agonist Receptor?

CD28, Costimulator or Agonist Receptor?

Changes in the state of a cell as it responds to signals delivered by soluble mediators as well as by engagement of ligands displayed on cell surfaces or on extracellular matrices are the basis of differentiation, development, and the activation of effector functions. The molecular mechanisms by which ligands of cell surface receptors elicit such changes occupy not only a large proportion of th...

A role for inducible costimulator protein in the CD28- independent mechanism of resistance to Toxoplasma gondii.

Long-term resistance to Toxoplasma gondii is dependent on the development of parasite-specific T cells that produce IFN-gamma. CD28 is a costimulatory molecule important for optimal activation of T cells, but CD28(-/-) mice are resistant to T. gondii, demonstrating that CD28-independent mechanisms regulate T cell responses during toxoplasmosis. The identification of the B7-related protein 1/ind...

An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization.

G protein-coupled receptor desensitization and trafficking are important regulators of opioid receptor signaling that can dictate overall drug responsiveness in vivo. Furthermore, different mu-opioid receptor (muOR) ligands can lead to varying degrees of receptor regulation, presumably because of distinct structural conformations conferred by agonist binding. For example, morphine binding produ...

Cell Survival: A Functional Link to CD28 as a Costimulator for IL-2 Induction and T Critical Role of TNF Receptor Type-2 (p75)

An Opioid Agonist that Does Not Induce -Opioid Receptor— Arrestin Interactions or Receptor Internalization

G protein-coupled receptor desensitization and trafficking are important regulators of opioid receptor signaling that can dictate overall drug responsiveness in vivo. Furthermore, different -opioid receptor ( OR) ligands can lead to varying degrees of receptor regulation, presumably because of distinct structural conformations conferred by agonist binding. For example, morphine binding produces...